He last thing Nepalis think when they meet Marie Ringler is that she is a politician. "You look like a rock star, " some say, others ask: "Are you a model?" But as a 27-year-old Green Party member of the Austrian federal state parliament for Vienna, Marie is used to such reactions. Here on a six-week placement with the US-based National Democratic Institute, she is preparing a report on ways to increase the representation of women in political parties in this country. We caught up with Marie during her visit to a school in Patan last week, where she asked a group of grade ten students how many wanted to become politicians. Only two hesitant hands went up. The rest wanted to know what was so great about politics anyway. Marie's answer: "You are in the middle of things, you can't just complain, you have to find solutions." More hands went up: what makes a good politician? "You have to like people, care about them, you need a will to learn and listen to what people want." And what does she think about Nepali politicians? Here, Marie is slightly diplomatic: "There is.
New York v. United States, 505 U.S. 144, 155 1992 ; . Peden v. City of Seattle, 510 P.2d 1169, 9 Wash.App. 106, review denied 82 Wash.2d 1010 1973 ; . 511 Engle v. Issac, 456 U.S. 107, 128 1982 Screws v. United States, 325 U.S. 91, 109 1945 ; . 512 "No state may.excuse its failure to perform a public duty." Champion v. Ames, 188 U.S. 321 1903 ; , citing Stone v. Mississippi, 101 U.S. 874 1879 ; . Even if a state wanted to allow Congress to exceed its constitutional authority, it could not do so: "State officials cannot consent to the enlargement of the powers of Congress beyond those enumerated in the Constitution." New York v. United States, supra, at 168-69 1992 ; . 513 See, e.g., Hammer v. Dagenhart, 247 U.S. 251 1918 and United States v. E.C. Knight Co., 156 U.S. 1 1895 ; . 514 See, e.g., United States v. Morrison, 529 U.S. 598 2000 Printz v. United States, 521 U.S. 898 1997 and United States v. Lopez, 514 U.S. 549 1995 ; . It is important to note, however, that the Rehnquist Court has invoked the Tenth Amendment to limit the reach of federal criminal law under the Commerce Clause, upon which current federal drug laws principally rely for their legitimacy. See Linda Greenhouse 2003 ; , "For a Supreme Court Graybeard, States' Rights Can Do No Wrong, " The New York Times, March 16, 2003, p.WK5. 515 Champion v. Ames, 188 U.S. 321 1903 Hoke v. United States, 277 U.S. 308 1913 ; . In Hamilton v. Kentucky Distilleries Co., 251 U.S. 146 1919 ; , the Court stated: "That the United States lacks the police power, and that this is reserved to the States by the Tenth Amendment, is true. But it is nonetheless true that when the ted States exerts any of the powers conferred on it by the Constitution, no valid objection can be based upon the fact that such exercise may be attended by the same incidents which attend the exercise by a State of its police power." at 151. 516 U.S. CONST. Art. I, sec. 8[3] 517 Gibbons v. Ogden, 22 U.S. 1 1824 ; , firmly established Congress' broad power to regulate interstate commerce but such commerce was not deemed to include business activities solely within any state. See, e.g., Paul v. Virginia, 8 Wall. 180 1869 and Kidd v. Pearson, 128 U.S. 1 1888 ; . 518 Interstate Commerce Commission v. Atchison Topeka & Santa Fe Railroad Co., 234 U.S. 294 1914 ; . 519 Stafford v. Wallace, 258 U.S. 495 1922 ; , relying on Swift v. United States, 196 U.S. 375 1905 ; . 520 See, e.g., National Labor Relations Board v. Jones & Laughlin Steel, 301 U.S. 1 1937 ; , recognizing federal commerce power over local manufacturing; and United States v. Darby, 312 U.S. 100 1941 ; , justifying any reasonable means to achieve federal ends. Even before the 1930s, the U.S. Supreme Court upheld federal powers in areas that had traditionally been seen as states' responsibilities. See, e.g., Hamilton v. Kentucky Distilleries Co., 251 U.S. 146 1919 ; . 521 Wickard v. Filburn, 317 U.S. 111 1942 Perez v. United States, 402 U.S. 146 1970 ; . 522 Heart of Atlanta Motel v. United States, 379 U.S. 241 1964 Katzenbach v. McClung, 379 U.S. 294 1964 Daniel v. Paul lake club snack bar ; 1969 ; . 523 Congress may regulate: 1 ; the channels of commerce; 2 ; the instrumentalities of commerce; and 3 ; those activities that substantially affect interstate commerce. U.S. v. Lopez, 514 U.S. 549, 556-557 1995 ; . 524 David G. Savage 2004 ; , "Finite Federalism, " American Bar Association Journal, July 2004, p. 22 525 Reid v. Colorado, 187 U.S. 137, 23 S.Ct. 92 1902 and Champion v. Ames, 188 U.S. 321 1903 ; . The Champion case also held, however, that "interstate commerce does not comprehend activities that take place entirely within a state's borders." at 346. 526 Gibbons v. Ogden, supra, 9 Wheat, 1, 196; see also Reid v. Colorado, 187 U.S. 137, 23 S.Ct. 92 1902 United States v. Delaware & Hudson Co., 213 U.S. 366 1909 James Clark Distilling Co. v. Western Maryland Railroad Co., 242 U.S. 311 1917 United States v. Hill, 248 U.S. 420, 39 S.Ct. 143 1919 and McCormick & Co., Inc. v. Brown, 286 U.S. 131, 52 S.Ct. 522, 87 A.L.R. 448 1932 ; . 527 See Part I, supra, "Drugs and the Drug Laws: Historical and Cultural Contexts, " pp. 18-21, discussing the strengthening of federal authority over drug control through judicial interpretation of the Harrison Act of 1914. 528 Daniel K. Benjamin & Roger Leroy Miller 1991 ; Undoing Drugs: Beyond Legalization, New York: Basic Books, p. 266. 529 Richard J. Bonnie & Charles H. Whitebread II 1974 ; , The Marijuana Conviction, Charlottesville: University Press of Virginia, p. 61. 530 See Part I, supra, "Drugs and the Drug Laws: Historical and Cultural Contexts, " pp. 21-25. 531 Pub.L. 91-513, October 27, 1970, 84 Stat. 1236.
One study concluded that there is a moderate improvement in the pain of diabetic neuropathy with capsaicin use.31 Capsaicin burns when applied to the and lamictal.
Many Courts of Appeals have noted the difficulties posed by class-treatment of mass products liability cases, although some have expressed a greater degree of skepticism than others. Compare Matter of Rhone-Poulenc Rorer, Inc., 51 F.3d 1293, 1304 7th Cir. 1995 ; noting criticism of the use of class actions in mass tort cases and decertifying class of hemophiliacs alleged to have contracted HIV following infusion of defendants' blood products ; , and Castano v. Am. Tobacco Co., 84 F.3d 734, 746 5th Cir.1996 ; decertifying class of smokers and noting that certification skews trial outcomes and increases pressure on defendants to settle ; , with Valentino v. CarterWallace, Inc., 97 F.3d 1227, 1233 9th Cir. 1996 ; decertifying pharmaceutical drug class but refusing to "close the door on class action litigation in products liability cases" ; , and Barnes v. Am. Tobacco Co., 161 F.3d 127, 142 3rd Cir. 1998 ; upholding decertification of class of smokers and noting that individualized issues tend to predominate in mass tort accidents that do not arise out of a single accident ; . Cf. In re Agent Orange Prod. Liab. Litigation, MDL No. 381, 818 F.2d 145, 151 2d Cir. 1987 ; expressing skepticism toward utility of class actions in the mass tort context but upholding certification of class of persons exposed to Agent Orange solely because the military contractor defense would apply in all cases ; . 8 See In re Aredia and Zome6a Prods. Liab. Litig., 06-MD-1760, 2007 WL 3012972 M.D. Tenn. Oct. 10, 2007 ; users of intravenousbisphosphonate drugs seeking dental monitoring for ONJ In re Vioxx Prods. Liab. Litig., 239 F.R.D. 450 E.D. La. 2006 ; recalled prescription pain medication In re Prempro Prods. Liab. Litig., 230 F.R.D. 555 E.D. Ark. 2005 ; menopause drug Foster v. St. Jude Medical, Inc., 229 F.R.D. 599, 604-05 D.C. Minn. 2005 ; heart bypass device Zehel-Miller v. Astrazenaca Pharmaceuticals, LP, 223 F.R.D. 659, 663 M.D. Fla. 2004 ; depression drug In re Baycol Prods. Litig., 218 F.R.D. 197 D. Minn. 2003 ; recalled cholesterol drug Perez v. Metabolife Int'l, Inc., 218 F.R.D. 262 S.D. Fla. 2003 ; recalled over-the-counter dietary supplement In re Paxil, 212 F.R.D. 539 C.D. Cal. 2003 ; drug prescribed to treat depression. However Teva, the world's largest generic drugmaker, said in a statement that a U.S. court had then granted an emergency request made by the Swiss-based firm Novartis for Teva to halt shipments of the drug that treats high blood pressure on the grounds of patent infringement." : reuters article health-SP idUSL2010245520070521 PHRMA TAKES AIM AT THAILAND FOR PRODUCTION OF GENERICS, HINTS THAT IT WILL PUSH FOR SANCTIONS 5 23, Ian Swanson, The Hill ; reports "Drug companies are making a concerted effort to increase pressure on Thailand and other developing countries to honor U.S. drug patents. The Pharmaceutical Research and Manufacturers Association PhRMA ; is alarmed by Thailand's decision to authorize the production of generic versions of two AIDS drugs that are still under U.S. company patents, as well as one cardiovascular drug." : thehill business--lobby ONWARD & UPWARD WITH THE ARTS MICHAEL MOORE'S HEALTH INDUSTRY DOCUMENTARY 'SICKO' DEBUTS [May 21, 2007, kff ] " The Wall Street Journal on Friday examined how supporters of documentary film maker Michael Moore's next film about the health care industry "hope that the new movie will stir up emotions and help generate the kind of buzz that made his last movie . a topic of national debate and an unprecedented blockbuster in the documentary genre." Moore has said that the film, called "SiCKO, " "will expose the health care industry's greed and control over America's political processes." Producer Harvey Weinstein said that the film "will ignite the country once and for all to deal with health care." According to the Journal, Moore "has largely kept a lid on the contents of the movie, " but "[r]umors started circulating" after nurses unions and health care experts saw the film. The Journal reports, "Picking a fight with the opposition is a key component of Mr. Moore's typical marketing plan, " and drug companies already have "started taking the bait." When Moore started working on the documentary, some drug companies sent warnings to employees not to speak with him. The Pharmaceutical Research and Manufacturers of America already has prepared a statement in response to the film, though no one at the organization has seen it. PhRMA Vice President Ken Johnson said, "No one should be surprised that Michael Moore is making baseless accusations designed to drum up publicity for his movie." He added that "SiCKO" was not on his organization's "top 10 list of concerns." America's Health Insurance Plans spokesperson Mohit Ghose said his organization will respond to the movie once officials view it but added that AHIP already is focusing on improving health care access and affordability. The film debuted over the weekend at the Cannes Film Festival and will open in U.S. theaters on June 29 Marr, Wall Street Journal, 5 18 ; ." FOR MICHAEL MOORE, CONTROVERSY IS MARKETING By MERISSA MARR, Wall St. Journal, May 18, 2007; Page B1 "Filmmaker Michael Moore says on his Web site that his new documentary, "SiCKO, " "will expose the health-care industry's greed and control over America's political processes." Controversy has become a key ingredient of marketing Mr. Moore's work, and the backers of "SiCKO" hope that the new movie will stir up emotions and help generate the kind of buzz that made his last movie, "Fahrenheit 9 11, " both a topic of national debate and an unprecedented blockbuster in the documentary genre. "Fahrenheit 9 11" had a budget of million and grossed more than 0 million in the U.S. alone. Mr. Moore's formula is simple: Pick a divisive topic and goad opponents into a public debate before the movie opens. The question is whether his new film's subject material -- health care and insurance -- will deliver the kind of heat that he generated for "Fahrenheit 9 11, " a movie about the Bush administration's actions before and after the Sept. 11th attacks. "SiCKO" makes its debut at the Cannes Film Festival this weekend and opens in U.S. theaters June 29. Movie producer Harvey Weinstein, who has worked on Mr. Moore's previous movies and whose company is financing, marketing and co-distributing this one, predicts his new release "will ignite the country once and for all to deal with health care." Unlike "Fahrenheit 9 11, " he says the movie will appeal to both ends of the political spectrum, though it may be difficult for Mr. Moore to win backing from conservatives he has previously lambasted. Mr. Moore's critics -- like Canadian documentarians Debbie Melnyk and Rick Caine, who recently released a movie that slammed his style -- say that he understands the appeal of a good brawl. "Michael knows the entertainment quotient trumps all, " says Ms. Melnyk. "Fahrenheit 9 11" had a lucky break early on when Walt Disney Co. refused to distribute it, a point Mr. Moore and company used to generate enormous amounts of free publicity for the film. To help build buzz for "SiCKO, " Mr. Weinstein brought back the "Fahrenheit 9 11" team, including political consultant Chris Lehane. Mr. Lehane is perhaps best known as an ex-adviser to Bill Clinton; he helped the former president and nitrofurantoin. Yes. Yes, even if daily dose for maintenance. Yes, if arthritis is inactive. Yes, if taken for allergies. Defer for 72 hours after symptoms are resolved if taken for cold flu symptoms or for fever. Defer 72 hrs for plateletpheresis or sole source platelets. Detected in 36% of patients on pamidronate and in 27% of patients in the control group.43 Interpretation of these results has to consider that an oral dose of 300 mg daily pamidronate seems to be too low to effectively reduce the incidence of bone metastases since oral bioavailability is only 1%. Furthermore, breast cancer patients of the pamidronate study were in an advanced cancer stage. Therefore, differences in study populations might have contributed to controversial results of the oral bisphosphonate prevention studies. The zoledronic acid preclinical and preliminary clinical data favor this new bisphosphonate over clodronate and pamidronate, and intravenous infusion therapy with zoledronic acid appears promising in the prevention of bone metastases and shall therefore be investigated in the present study. This protocol contains a substudy measuring bone mineral density in men with high risk prostate cancer starting with hormone therapy. In a recently completed trial Zmeta Protocol 705 ; , Zometa4 mg given as a 15-minute intravenous infusion every 12 weeks for one year 5 treatments ; significantly increased lumbar spine and hip bone mineral density compared to placebo in 106 men with prostate cancer who were beginning androgen deprivation therapy.44 Men who received the Zomwta infusions had an increase in lumbar spine bone mineral density BMD ; of 5.16% p 0.001 vs. placebo ; . BMD increased by 1.08% in the total hip, 1.64% at the femoral neck, 2.37% at the trochanteric region, and 3.39% at Ward's triangle, and decreased by 2.62%, 1.85%, 2.45%, and 0.58%, respectively, at these sites in the placebo group p 0.001 for difference between zoledronic acid and placebo at the total hip, femoral neck, and trochanteric regions, respectively ; . It is expected that in the present study Zojeta in addition to the prevention of bone metastases will show its potential in preventing hormone therapy induced bone loss and imodium.
Desirability of applying for a review or, if necessary, filling an appeal or application for revision may be considered. General instru- 41. Ctions for the law Officer. 1 ; The Law Officer concerned shall endeavour to obtain form time to time such information as amy lead to the recovery of any money due to Governemnt and furnish to the administrative department concerned any information which comes to his knowledge and which is likely to facilitate the recovery of the moneys due to Government. 2 ; He shall be responsible for seeing that the execution of any decree is hot barred by limitation. When the period of limitation for the execution of any decree is nearly expiring, without such decrees having been fully satisfied , he shall specially bring that fact to the notice of the administrative department concerned. Enquiries as to 42. The property and Means of the Judgement debtor. 1 ; The administrative department concerned shall, whenever necessary, though the collector concerned or otherwise, make enquires as to the property and means of the judgement-debtor and endeavour to recover from him the whole or such portion of the amount due as may be possible. 2 ; For the purpose of making any such enquires , the administrative department concerned may employ such trustworthy agency as fit may think fit any may pass bonafide traveling expenses incurred by the person deputed to make such enquiry. Upon the court issuing orders for the attachemtn of the judgement debtor's property, the Law Officer concerned shall at once apply to the administrative department concerned to depute some one to accompany the attaching officer and to point out the property. In case claims are made by third parties to the property attached, the Government Officer onwhose report the property was attached shall collect the evidence which would show that the property belongs to the judgement debtor, and he shall, if possible , be present in the Court and instruct the Law Officer concerned , when the Courts is inquiring into the claim and colace.
From Surety indicating they agreed with Dr. Nicola's IME. However, in response to a letter from Claimant's attorney, Dr. Dubose later wrote that he felt Claimant's low back and radicular symptoms are more likely than not related to his accident since there was no previous history, and he opined Claimant should undergo at least one more lumbar epidural steroid injection. He further noted Claimant had a strong psychiatric overlay and aggressive surgical or procedural intervention should not be done without additional evaluation and ongoing management. 33. As described in many of the medical records, Claimant presented at hearing with.
Some pain medicines can cause you to feel sleepy when you first take them. This feeling usually goes away within a few days. Sometimes you become drowsy because, with the relief of the pain, you are now able to catch up on the much needed sleep you missed when you were in pain. On occasion, people get dizzy or feel confused when they take pain medicines. Tell your doctor or nurse if this happens to you. Changing your dose or type of medicine can usually solve the problem and depakote.
Meal plan to keep your blood glucose under control. Kidney disease. If you have or develop kidney problems, you will need to follow a special meal plan.
To-date information on this meeting. ttee will discuss supplemental new drug application NDA ; 21-386, ZOMETA z~ledr~nic acid for injection ; , Novartis Pharmaceuticals Corp., indicated fur the one metastases in patients with multiple myeloma, breast cancer, prostate cancer and other solid tumors. Procedure: Intereste persons may present data, infurmation, or views, orally or in writing, on issues lending before the committee. Written submissions may be made to the contact person and imuran.
OCD involves having both obsessions and compulsions. A person with OCD may sometimes have one or the other. Common obsessions are: contamination fears of germs, dirt, etc. imagining having harmed self or others, imagining losing control or aggressive urges, intrusive sexual thoughts or urges, excessive religious or moral doubt, forbidden thoughts A need to have things "just so" A need to tell, ask, confess common compulsions: washing repeating checking touching counting OCD symptoms can occur in people of all ages. Not all Obsessive-Compulsive behaviors represent an illness. Some rituals e.g., bedtime songs, religious practices ; are a welcome part of daily life. Normal worries, such as contamination fears, may increase during times.
Neurologic Pain Seminar HCA Coliseum Medical Center, Macon, Georgia Title: Neurooncologic Pain Syndromes Medical Staff Annual Meeting Northshore Medical Center, Miami, Florida Title: Pain Centers and Neurodiagnostic Strategies CNN, Cable News Network Atlanta, Georgia Title: Anaprox as an OTC Medication Global Business Research Ltd., "Clinical Trials: Accelerating Development in a Cost-Conscious Era", Philadelphia, Pennsylvania Title: Multicenter Private Providers: An Emerging Vehicle for Clinical Trials Tumor Board Conference West Paces Medical Center, Atlanta, Georgia Title: Pain and Breast Cancer: The Pain Syndrome Study Project - A Multicenter Prospective Outcome Study on Malignant and Non-Malignant Pain Syndromes seen in Breast Cancer Patients The Neurodiagnostic Center Atlanta, Georgia Title: Reflex Sympathetic Dystrophy North Shore Medical Center Miami, Florida Title: Usage of Diagnostic and Therapeutic Block Procedures with Various Pain Conditions Private Rehabilitation Suppliers Meeting Callanwolde Conference Center, Atlanta, Georgia Title: Post-Concussive Syndrome CNA Insurance Company Atlanta, Georgia Title: Reflex Sympathetic Dystrophy The Neurodiagnostic Center, Parkway Medical Center Lithia Springs, Georgia Title: Surgical and Non-Surgical Low Back Pain Universal Medical Center Educational Seminar Plantation, Florida Title: SMP Overview of Diagnostic and Treatment Issues State Farm Insurance Company Atlanta, Georgia Title: IMEs and PPD Ratings Related to Back and Spine Injuries and cytoxan and Cheap zometa.
Event for the proportion of patients with a SRE of Zometa 4 mg versus placebo. ratio for the first occurrence of a SRE of Zometa 4 mg versus placebo.
Prostate cancer spreads to the surrounding bones metastasis ; . Zometa is delivered by intravenous infusion and works to strengthen bone tissue and prevent the loss of bone density. This has been show to reduce some of the effects of bone metastases such as fractures, bone lesions and bone pain. For more information: zometa ; . Zoladex is commonly used in advanced stage prostate cancer. It is part of a class of drugs called anti-androgens, which block the body's production of testosterone. Cancer cells need testosterone in order to grow. Treatment with Zoladex starves the tumour, so to speak, slowing or arresting its growth. Research has shown that treatment with Zoladex, in conjunction with radiation therapy, can prolong survival in advanced stage prostate cancer patients. In the past two years it has been found that treatment with antiandrogen hormonal agents may be associated with loss of bone density osteoporosis ; * in a significant number of men. The new study will assess the value of adding treatment with Zometa to the medication regimen of patients who would normally be treated with Zoladex alone. Half of the men in the study will receive regular doses of Zoladex only and and levothroid.
NUTRITIONAL EFFECTS OF DIETARY MODIFICATION IN EARLY CANINE CHRONIC VALVULAR DISEASE. LM Freeman, JE Rush, PJ Markwell. Tufts University School of Veterinary Medicine, North Grafton, MA, USA & WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire, England. The purpose of this study was to assess the nutritional effects of a moderately reduced sodium diet enriched with n-3 fatty acids, antioxidants, B vitamins, and certain amino acids cardiac diet ; in dogs with chronic valvular disease CVD ; . Dogs with asymptomatic CVD International Small Animal Cardiac Health Council class 1a or 1b ; were studied. After a baseline cardiac evaluation, blood was collected for a biochemistry profile and for measurement of thiamine, amino acids, vitamins C and E, 8-F2-isoprostanes, nitrite nitrate, and fatty acids. Urine glycosaminoglycans GAGs ; also were analyzed. After baseline measurements in the dogs with CVD were compared to those of healthy control dogs, all dogs with CVD were changed from their usual diets to a run-in diet to ensure that all were eating the same diet before starting the cardiac or placebo diets. After 4 weeks of exclusive feeding of the run-in diet, dogs were re-evaluated and then randomized to receive either the cardiac diet or a placebo diet exclusively in a double-blind fashion. A final evaluation was performed after dogs had eaten the cardiac or placebo diet for 4 weeks. All measurements obtained at baseline were repeated at the 4and 8-week visits. At baseline, there were no significant differences between the CVD n 29 ; and healthy control groups n 12 ; in median age CVD: 8 yrs, range 4-14 yrs; Controls: 9 yrs, range 5-11 yrs ; or median body weight CVD: 8.9 kg, range 5.7-29.5 kg; Controls: 10.1 kg, range 3.9-21.0 kg ; . Dogs with CVD had significantly lower baseline serum sodium and chloride concentrations compared to the healthy controls. A number of plasma amino acids, including methionine, cystathionine, and arginine, also were found to be different between the CVD dogs and healthy controls at baseline. After 4 weeks of exclusively eating either the cardiac n 14 ; or placebo n 15 ; diets, vitamins C and E, cholesterol, and triglyceride concentrations increased significantly more in the cardiac diet group. Thiamine concentrations increased significantly in the cardiac group but not in the placebo group and there was a significant decrease in taurine concentrations for dogs in the placebo group but not in the cardiac diet group. Plasma nitrite nitrate concentrations increased significantly in both diet groups. These results suggest that dietary modification can alter certain circulating antioxidants and amino acids that may be beneficial in dogs with early CVD.
7. Durie BGM, Katz M, McCoy J, Crowley J. Osteonecrosis of the jaws in myeloma: time dependent correlation with Aredia and Zometa use. Soc Hematol 2004; 104: 216a Abstr 756 ; . 8. Damato K, Gralow J, Hoff A et al. Expert panel recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaws. Dockets Management, US Food and Drink Administration, June 2004; fda.gov ohrms dockets ac 05 briefing 20054095B2 02 12-Novartis-Zometa-App-11 . 9. Travis K, Zielinski SL. In Brief. J Natl Cancer Inst 2004; 96: 1572.
The active ingredient of Zometa is a bisphosphonate, zoledronic acid, or 1-hydroxy-2- 1H-imidazol-1-yl ; ethane-1, 1-diphosphonic acid monohydrate. The chemical structure of zoledronic acid is.
Table No.23 Short Course Regimen Children 0-14 years old ; Initial intensive Phase Weight of patient Pretreatment.
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